D-glutamate
D-glutamate is a small molecule pharmaceutical. It is currently being investigated in clinical studies.
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Drug Products
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New Drug Application (NDA)
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Abbreviated New Drug Application (ANDA)
Abbreviated New Drug Application (ANDA)
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Labels
FDA
EMA
Brand Name | Status | Last Update |
|---|---|---|
| clinisol | ANDA | 2018-06-01 |
| kabiven | New Drug Application | 2023-08-02 |
| perikabiven | New Drug Application | 2023-08-07 |
| plenamine | ANDA | 2023-04-21 |
| premasol - sulfite-free (amino acid) | ANDA | 2022-08-04 |
| prosol | New Drug Application | 2020-10-07 |
| trophamine | New Drug Application | 2023-11-27 |
Indications
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Agency Specific
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Clinical
Clinical Trials
489 clinical trials
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Depression | D003863 | — | F33.9 | 8 | 13 | 4 | 5 | 16 | 45 |
| Non-small-cell lung carcinoma | D002289 | — | — | 10 | 21 | 13 | 1 | 1 | 40 |
| Major depressive disorder | D003865 | EFO_0003761 | F22 | 7 | 12 | 4 | 4 | 13 | 40 |
| Depressive disorder | D003866 | EFO_1002014 | F32.A | 4 | 9 | 4 | 2 | 12 | 31 |
| Schizophrenia | D012559 | EFO_0000692 | F20 | 5 | 6 | 5 | 4 | 5 | 24 |
| Alcoholism | D000437 | EFO_0003829 | F10.1 | 3 | 6 | — | 2 | 4 | 15 |
| Bipolar disorder | D001714 | EFO_0000289 | F30.9 | 2 | 4 | 1 | 2 | 5 | 14 |
| Obsessive-compulsive disorder | D009771 | EFO_0004242 | F42 | 2 | 9 | — | 1 | 3 | 13 |
| Parkinson disease | D010300 | EFO_0002508 | G20 | 2 | 8 | — | 1 | 2 | 11 |
| Psychotic disorders | D011618 | — | F20.81 | 1 | 2 | — | 3 | 5 | 11 |
Show 47 more
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Lung neoplasms | D008175 | — | C34.90 | 3 | 13 | 5 | — | 3 | 22 |
| Healthy volunteers/patients | — | — | — | 13 | 5 | 1 | — | 4 | 21 |
| Diabetes mellitus | D003920 | EFO_0000400 | E08-E13 | 2 | 7 | 2 | — | 3 | 12 |
| Type 1 diabetes mellitus | D003922 | EFO_0001359 | E10 | 2 | 8 | 2 | — | 2 | 12 |
| Carcinoma | D002277 | — | C80.0 | 6 | 7 | 1 | — | — | 11 |
| Syndrome | D013577 | — | — | — | 3 | 2 | — | 6 | 11 |
| Treatment-resistant depressive disorder | D061218 | — | — | 2 | 4 | 1 | — | 3 | 10 |
| Adenocarcinoma | D000230 | — | — | 3 | 5 | 1 | — | 1 | 10 |
| Ovarian neoplasms | D010051 | EFO_0003893 | C56 | 4 | 3 | 1 | — | — | 7 |
| Recurrence | D012008 | — | — | 2 | 3 | 1 | — | 2 | 7 |
Show 76 more
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Prostatic neoplasms | D011471 | — | C61 | 4 | 12 | — | — | 3 | 19 |
| Neoplasms | D009369 | — | C80 | 7 | 5 | — | — | 1 | 11 |
| Pancreatic neoplasms | D010190 | EFO_0003860 | C25 | 7 | 8 | — | — | — | 9 |
| Breast neoplasms | D001943 | EFO_0003869 | C50 | 5 | 4 | — | — | 2 | 9 |
| Compulsive personality disorder | D003193 | — | F60.5 | 1 | 5 | — | — | 2 | 7 |
| Brain injuries | D001930 | — | S06.9 | 1 | 5 | — | — | — | 6 |
| Stroke | D020521 | EFO_0000712 | I63.9 | — | 4 | — | — | 2 | 6 |
| Autistic disorder | D001321 | EFO_0003758 | F84.0 | 3 | 1 | — | — | 2 | 6 |
| Castration-resistant prostatic neoplasms | D064129 | — | — | 1 | 5 | — | — | — | 6 |
| Triple negative breast neoplasms | D064726 | — | — | 3 | 4 | — | — | — | 5 |
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Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Obesity | D009765 | EFO_0001073 | E66.9 | 1 | — | — | — | 3 | 4 |
| Pervasive child development disorders | D002659 | EFO_0003756 | F84 | 1 | — | — | — | 2 | 3 |
| Human influenza | D007251 | EFO_0007328 | J11.1 | 3 | — | — | — | — | 3 |
| Pulmonary hypertension | D006976 | EFO_0001361 | I27.20 | 1 | — | — | — | 1 | 2 |
| Consciousness disorders | D003244 | — | — | 1 | — | — | — | 1 | 2 |
| Marijuana abuse | D002189 | EFO_0007191 | F12 | 2 | — | — | — | — | 2 |
| Positron-emission tomography | D049268 | — | — | 1 | — | — | — | 1 | 2 |
| Pharmacokinetics | D010599 | — | — | 2 | — | — | — | — | 2 |
| Severe acute respiratory syndrome-related coronavirus | D045473 | NCBITaxon_227859 | — | 2 | — | — | — | — | 2 |
| Disease | D004194 | EFO_0000408 | R69 | 1 | — | — | — | 1 | 2 |
Show 19 more
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Burns | D002056 | — | T30.0 | — | — | — | — | 5 | 5 |
| Migraine disorders | D008881 | EFO_0003821 | G43 | — | — | — | — | 3 | 3 |
| Chronic obstructive pulmonary disease | D029424 | EFO_0000341 | J44.9 | — | — | — | — | 2 | 2 |
| Sars-cov-2 | D000086402 | — | — | — | — | — | — | 2 | 2 |
| Nervous system diseases | D009422 | — | G00-G99 | — | — | — | — | 2 | 2 |
| Post-traumatic stress disorders | D013313 | EFO_0001358 | F43.1 | — | — | — | — | 2 | 2 |
| Irritable bowel syndrome | D043183 | EFO_0000555 | K58 | — | — | — | — | 2 | 2 |
| Systemic lupus erythematosus | D008180 | EFO_0002690 | M32 | — | — | — | — | 2 | 2 |
| Amyotrophic lateral sclerosis | D000690 | EFO_0000253 | G12.21 | — | — | — | — | 2 | 2 |
| Motor neuron disease | D016472 | EFO_0003782 | G12.2 | — | — | — | — | 2 | 2 |
Show 82 more
Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | D-glutamate |
| INN | — |
| Description | D-glutamic acid is an optically active form of glutamic acid having D-configuration. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a D-alpha-amino acid and a glutamic acid. It is a conjugate acid of a D-glutamate(1-). It is an enantiomer of a L-glutamic acid. |
| Classification | Small molecule |
| Drug class | — |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | N[C@H](CCC(=O)O)C(=O)O |
Identifiers
| PDB | — |
| CAS-ID | 6893-26-1 |
| RxCUI | — |
| ChEMBL ID | CHEMBL76232 |
| ChEBI ID | 15966 |
| PubChem CID | 23327 |
| DrugBank | DB02517 |
| UNII ID | — |
Target
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Variants
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Financial
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Trends
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Safety
Black-box Warning
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Adverse Events
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314 adverse events reported
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